Welcome to Zou Lab
Welcome to our lab at College of Chemistry and Molecular Engineering, Peking University!
We aim to invent chemical and biophysical tools to map neuronal activities at high spatiotemporal resolution. We apply these tools to investigate the underlying biological macromolecules, physical forces, and chemical signaling that give rise to neuronal functions. Examples are engineered enzymes, fluorescent indicators, custom-built microscopes and software, etc.
Our methods are drawing from a wide range of techniques, including protein engineering, chemical synthesis, molecular and cellular biology, fluorescence microscopy, high-throughput sequencing, mass spectrometry-based proteomics, and quantitative modeling.
Current research projects include:
- Optical mapping of action potential waveforms with genetically-encoded voltage indicators
- Chemical labeling technique for high-resolution mapping of proteins and RNAs in living cells
- Proximity tagging methods for profiling synaptic protein synthesis
Selected Publications
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A far-red hybrid voltage indicator enabled by bioorthogonal engineering of rhodopsin on live neurons
Liu, S.#, Lin, C.#, Xu, Y.# et al. Nat. Chem., 2021
Mapping spatial transcriptome with light-activated proximity-dependent RNA labeling
Wang, P.#, Tang, W.#, Li, Z.# et al. Nat. Chem. Biol., 2019
Chromophore-assisted proximity labeling of DNA reveals chromosomal organization in living cells
Ding, T.#, Zhu, L.# et al. Angew. Chem. Int. Ed. Engl., 2020
The evolving capabilities of enzyme-mediated proximity labeling
Zhou, Y. and Zou, P. Curr. Opin. Chem. Biol., 2020
A clickable APEX probe for proximity-dependent proteomic profiling in yeast
Li, Y. et al. Cell Chem. Biol., 2020
Zhou, Y.#, Wang, G.# et al. Angew. Chem. Int. Ed. Engl., 2019
Recent News
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Happy 2022!
Jan 1, 2022We celebrated New Year by exchanging gifts and sharing our loving memories of 2021.
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Hybrid Indicator Review
Sept 15, 2021Check out our recently published review on hybrid voltage indicators.
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Tenure Promotion
Aug 12, 2021Peng is Promoted to Tenured Associate Professor.
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Welcome, Undergrads!
June 27, 2021Four students joined us this year for their undergraduate research training program.
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9x Thesis Defense!
June 19, 2021Congratulations to four graduate students and five undergrads who have recently defended their theses.
Links
About Us
Peking University, Beijing, 100871, China
Tel: +86-10-62745395
Email: zoupeng_at_pku.edu.cn
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