Welcome to our lab at College of Chemistry and Molecular Engineering, Peking University!
We aim to invent chemical and biophysical tools to map neuronal activities at high spatiotemporal resolution. We apply these tools to investigate the underlying biological macromolecules, physical forces, and chemical signaling that give rise to neuronal functions. Examples are engineered enzymes, fluorescent indicators, custom-built microscopes and software, etc.
Our methods are drawing from a wide range of techniques, including protein engineering, chemical synthesis, molecular and cellular biology, fluorescence microscopy, high-throughput sequencing, mass spectrometry-based proteomics, and quantitative modeling.
Current research projects include:
Check out our movies recording the dynamics of action potentials during its initiation at the AIS and its back-propagation to somatodendrites.
Four PhD students and three undergraduates have defended their thesis during the past month. Congratulations to all of you!
We report a photocatalytic reaction for mapping RNA-protein interactions in live cells.
Check out our recent work on resolving newly transcribed RNAs with subcellular resolution.
Welcome Chenxin Yu and Luming Yang to join us this semester for completing their undergraduate thesis research.
We celebrated New Year by exchanging gifts and sharing our loving memories of 2021.