Welcome to Zou Lab
Welcome to our lab at College of Chemistry and Molecular Engineering, Peking University!
We aim to invent chemical and biophysical tools to map neuronal activities at high spatiotemporal resolution. We apply these tools to investigate the underlying biological macromolecules, physical forces, and chemical signaling that give rise to neuronal functions. Examples are engineered enzymes, fluorescent indicators, custom-built microscopes and software, etc.
Our methods are drawing from a wide range of techniques, including protein engineering, chemical synthesis, molecular and cellular biology, fluorescence microscopy, high-throughput sequencing, mass spectrometry-based proteomics, and quantitative modeling.
Current research projects include:
- Optical mapping of action potential waveforms with genetically-encoded voltage indicators
- Chemical labeling technique for high-resolution mapping of proteins and RNAs in living cells
- Proximity tagging methods for profiling synaptic protein synthesis
Selected Publications
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A clickable APEX probe for proximity-dependent proteomic profiling in yeast
Li, Y.# et al. Cell Chem. Biol., 2020
Genome-wide mapping of oxidative DNA damage via engineering of 8‑oxoguanine DNA glycosylase
Fang, Y. and Zou, P.* Biochemistry, 2020
Mapping spatial transcriptome with light-activated proximity-dependent RNA labeling
Wang, P.#, Tang, W.#, Li, Z.# et al. Nat. Chem. Biol., 2019
Zhou, Y.#, Wang, G.# et al. Angew. Chem. Int. Ed. Engl., 2019
Hybrid indicators for fast and sensitive voltage imaging
Xu, Y.#, Peng, L.#, Wang, S.#, Wang, A.# et al. Angew. Chem. Int. Ed. Engl., 2018
Recent News
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Welcome Dr. Zhang!
July 9, 2020We are delighted to welcome Dr. Wei Zhang to join our group as a postdoctoral fellow! ...
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Cloud Commencement Ceremony
July 2, 2020Congratulations to Chaoling, Fu, Tenghui, and Wentao for successfully defending their undergraduate thesis and obtaining Bachlor of Science degrees! ...
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Welcome, Undergrads!
July 1, 2020We have an unusually large pool of students joining our lab for the Undergraduate Research Training Program this year. Welcome all of you! ...
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APEX Goes Microbial!
May 29, 2020We now present an improved APEX probe, Alk-Ph, for efficient spatially restricted proteomic and transcriptomic profiling in yeast cells.
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CAPA Award
May 15, 2020Peng received the 2020 OKeanos-CAPA Young Investigator Award! ...
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New Graduate Students
March 30, 2020Chang Lin and Ziqi Ren officially joined our lab as first year CCME graduate students! ...
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Meeting Online
Feb 18, 2020We resumed group meetings amidst the coronavirus outbreak. Stay healthy, stay connected! ...
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A DNA Trap
Jan 14, 2020Congratulations to Yuxin's enTRAP-seq paper, published in the special issue of Biochemistry! ...
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An RNA Map
Oct 9, 2019Check out our CAP-seq method for mapping RNA localization in live cells in Nat Chem Biol! ...
Links
About Us
Peking University, Beijing, 100871, China
Tel: +86-10-62745395
Email: zoupeng_at_pku.edu.cn
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