Welcome to Zou Lab
Welcome to our lab at College of Chemistry and Molecular Engineering, Peking University!
We aim to invent chemical and biophysical tools to map neuronal activities at high spatiotemporal resolution. We apply these tools to investigate the underlying biological macromolecules, physical forces, and chemical signaling that give rise to neuronal functions. Examples are engineered enzymes, fluorescent indicators, custom-built microscopes and software, etc.
Our methods are drawing from a wide range of techniques, including protein engineering, chemical synthesis, molecular and cellular biology, fluorescence microscopy, high-throughput sequencing, mass spectrometry-based proteomics, and quantitative modeling.
Current research projects include:
- Optical mapping of action potential waveforms with genetically-encoded voltage indicators
- Chemical labeling technique for high-resolution mapping of proteins and RNAs in living cells
- Proximity tagging methods for profiling synaptic protein synthesis
Selected Publications
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A far-red hybrid voltage indicator enabled by bioorthogonal engineering of rhodopsin on live neurons
Liu, S.#, Lin, C.#, Xu, Y.# et al. Nat. Chem., 2021
Mapping spatial transcriptome with light-activated proximity-dependent RNA labeling
Wang, P.#, Tang, W.#, Li, Z.# et al. Nat. Chem. Biol., 2019
Chromophore-assisted proximity labeling of DNA reveals chromosomal organization in living cells
Ding, T.#, Zhu, L.# et al. Angew. Chem. Int. Ed. Engl., 2020
The evolving capabilities of enzyme-mediated proximity labeling
Zhou, Y. and Zou, P. Curr. Opin. Chem. Biol., 2020
A clickable APEX probe for proximity-dependent proteomic profiling in yeast
Li, Y. et al. Cell Chem. Biol., 2020
Zhou, Y.#, Wang, G.# et al. Angew. Chem. Int. Ed. Engl., 2019
Recent News
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Welcome, Undergrads!
June 27, 2021Four students joined us this year for their undergraduate research training program.
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9x Thesis Defense!
June 19, 2021Congratulations to four graduate students and five undergrads who have recently defended their theses.
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Welcome Yu Chen and Chen Li
May 4, 2021Two CLS graduate students with Pchem and Organic chem backgrounds have recently joined us.
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Next-gen Hybrid Indicators
April 17, 2021Check out our new paper on all-optical electrophysiology with hybrid voltage indicators (HVIs) at Nature Chemistry!
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Happy New Year
Jan 1, 2021Although 2020 has been a difficult year, we are doing a great job coping with COVID-19, surviving and thriving.
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Bayer Investigator
Sept 24, 2020Peng is honored to receive 2020 Bayer Investigator Award from Bayer-Peking University Center for Translational Research.
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CIBR Young Scholar
Aug 17, 2020Peng is selected as CIBR Young Scholar by Chinese Institute for Brain Research (CIBR).
Links
About Us
Peking University, Beijing, 100871, China
Tel: +86-10-62745395
Email: zoupeng_at_pku.edu.cn
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