Welcome to our lab at College of Chemistry and Molecular Engineering, Peking University!

We aim to invent chemical and biophysical tools to map neuronal activities at high spatiotemporal resolution. We apply these tools to investigate the underlying biological macromolecules, physical forces, and chemical signaling that give rise to neuronal functions. Examples are engineered enzymes, fluorescent indicators, custom-built microscopes and software, etc.

Our methods are drawing from a wide range of techniques, including protein engineering, chemical synthesis, molecular and cellular biology, fluorescence microscopy, high-throughput sequencing, mass spectrometry-based proteomics, and quantitative modeling.

Current research projects include:

• Optical mapping of action potential waveforms with genetically-encoded voltage indicators
• Chemical labeling technique for high-resolution mapping of proteins and RNAs in living cells
• Proximity tagging methods for profiling synaptic protein synthesis