Four students joined us this year for their undergraduate research training program. Welcome Wenyu Ding, Han Wang, Ruijie Li, and Peiyuan Meng!
Over the past month, four graduate students (Wei, Ying, Tao, Anqi) and five undergrads (Luorong, Ziqin, Songrui, Guanghan, Zhiwei) have defended their theses. Congratulations to all of you! We celebrated these special occasions with a lab retreat that featured both stunning stalagmite and a fierce water fight.
Yu and Chen are enrolled in the CLS graduate program and have just finished their rotations. Both were undergraduates at CCME and trained in physical chemistry (Yu) and organic chemistry (Chen) labs. Welcome to join us and bring in new skill sets to our lab! They will work on projects related to spatial transcriptomics.
Our hybrid voltage indicator (HVI) paper is officially online at Nature Chemistry! Since the inception of Flare indicator in 2018, we have been working hard to implement this strategy in live neurons. Thanks to Diels-Alder reaction, we are able to assemble a palette of bright and sensitive HVIs in cultured rat hippocampal neurons. The most red-shifted HVI-Cy5 faithfully reports neuronal spikes in the far-red emission range and could be paired with optogenetic actuators and green/red-emitting fluorescent indicators, allowing multiplexed imaging and all-optical electrophysiology. We look forward to using this expanded toolbox in the high-throughput screening of neuronal ion channel agonists/antagonists. Congratulations to Shuzhang, Chang, Yongxian, and our collaborators in Prof. Peng Chen's group at PKU. To read more about the history of this work, check out our "Behind the Paper" post at Nature Portfolio Chemistry Community.
Although 2020 has been a difficult year for all of us, we are doing a great job coping with COVID-19. Surviving and thriving, we are looking forward to a brighter 2021! In our annual party, we exchanged gifts and shared memories of the past year. Congratulations to our 2020 Lab Stars - Shuzhang, Ruixuan, Luxin, Feng, Ran, Wei, Yi, Ying, Ruirui, Yuxin, Gang, Junqi, Ruixiang, and Chang. Thank you all for working hard to make our lab a better place!
Peng is honored to receive 2020 Bayer Investigator Award from Bayer-Peking University Center for Translational Research.
Peng is selected as CIBR Young Scholar by Chinese Institute for Brain Research (CIBR).
We are delighted to welcome Dr. Wei Zhang to join our group as a postdoctoral fellow! Wei did his graduate study in molecular neuroscience at the Cajal Institute of Spanish National Research Council, where he investigated the mechanisms by which neurons establish and maintain cellular polarity. He obtained his PhD from Universidad Autónoma de Madrid (UAM) in Spain at the end of 2019.
For the first time, we are having the Commencent ceremony online. Congratulations to Chaoling, Fu, Tenghui, and Wentao for successfully defending their undergraduate thesis and obtaining Bachlor of Science degrees! Chaoling, Fu, and Wentao will continue their PhD study in our department, while Tenghui has decided to defer his enrollment at the Scripps Research Institute at Florida Campus for one year to stay with us as a research assistant. Wish you all continued success!
We have an unusually large pool of students joining our lab for the Undergraduate Research Training Program this year. Welcome Haoyun An, Rui Fu, Yi Han, Haoran Hu, Wenyu Kuang, Lihao Liu, Xiao Niu, Xuefeng Wang, and Zekun Wang! They will work on a diverse array of topics, ranging from super-resolution microscopy to directed evolution.
Check out our recent development of APEX labeling in yeast at Cell Chem Biol! By using a clickable APEX2 substrate, Alk-Ph, we have achieved proximity-dependent protein and RNA labeling in intact yeast cells. This new approach enables the proteomic and transcriptomic mapping of yeast mitochondrial matrix with high spatial resolution and coverage, thus extending APEX applications to microorganisms. We thank our collaborator, Dr. Jing Yang from Beijing Proteome Research Center. Congratulations to Yi!
Peng is honored and humbled to receive the 2020 OKeanos-CAPA Young Investigator Award at the Chemical and Biology interface. We thank CAPA (the Chinese-American Chemistry and Chemical Biology Professors Association) for the recognition of our work in chemical neuroscience.
Chang Lin and Ziqi Ren officially joined our lab as first year CCME graduate students! Both of them did undergrad research here, working on fluorescence voltage indicator and proximity-dependent RNA labeling. Welcome both of you!
We resumed group meetings amidst the coronavirus outbreak, but had to use an online forum. Stay healthy, stay connected!
Congratulations to Yuxin's enTRAP-seq paper, published in the special issue of Biochemistry! As you read this news, your DNA is continuously under attack by reactive metabolites (particularly endogenous oxidants). Meanwhile, your cells are busy clearing up the resulting DNA damages, which have ramifications in tumorigenesis and gene expression control. To help illuminate the cellular mechanisms and the functional roles of oxidative DNA damage, we developed a genome-wide 8-oxoguanine profiling technique, termed enzyme-mediated trapping and affinity precipitation of damaged DNA and sequencing, or enTRAP-seq for short. When applied to analyze guanine oxidation in mouse embryonic fibroblast cells, enTRAP-seq revealed the enrichment of 8-oxoguanine in transcriptionally active chromatin regions.
We exchanged gifts and memorable moments of 2019 at the New Year party. This year's Lab Stars are: Ruixuan, Luxin, Ran, Ying, Wei, Ruirui, Shuzhang, Gang, Yuxin, and Feng. Congratulations and thank you all for your hard work!
Congratulations to Shuzhang for winning the poster award! He presented a bright and sensitive far-red voltage indicator for visualizing membrane potential dynamics in cultured neurons.
Check out our CAP-seq technique for mapping subcellular RNA localization at Nat Chem Biol! We employed a genetically encoded photosensitizer to achieve light-activated, proximity-dependent RNA oxidation, which allowed us to examine the local transcriptomes at various subcellular compartments. CAP-seq has high spatiotemporal resolution and is easy to use. We look forward to seeing more of its applications in the near future! We thank our collaborator, Prof. Jianbin Wang from Tsinghua University. Congratulations to Pengchong, Wei and Zeyao!
Congratulations to Yongxian Xu (on 9/6) and Pengchong Wang (on 9/10) for defending their doctoral theses!
Peng Zou has been selected by Chemical and Engineering News (C&EN) as a member of this year's Talented 12 list. This program is presented annually by the newsmagazine and recognizes 12 young stars in the chemical sciences who are "working to solve some of the world's most challenging problems". This news was announced at the American Chemical Society National Meeting in San Diego, CA.
Congratulations to Xiaotian Bi, Ziqi Ren, Chang Lin, and Liyuan Zhu (left to right) for getting their Bachelor's degrees! Ziqi and Chang will continue their study at PKU as graduate students. Xiaotian (Caltech) and Liyuan (Princeton) will start their PhD journey in the US after the summer. We look forward to seeing your continued success in the years to come. Congratulations again to all of you!
Check out our new panel of APEX substrates in Angewandte Chemie International Edition! We synthesized a series of aromatic compounds and identified arylamines as efficient probes for labeling RNA and DNA. Using the mitochondria as a model, we demonstrated proximity-dependent RNA capture with exceptional spatial-specificity and high coverage. Congratulations to Ying and Gang! This is our first venture into the RNA world.
Yi Li, Ruixiang Wang, and Xinyue Zhou joined our lab as first graduate students. Yi did his undergrad research in our group and has since decided to stay. Both Ruixiang and Xinyue were from Nankai University. They are enrolled in CLS program and have recently finished rotations. They will work on research projects related to proximity proteomic labeling.
As a lab tradition, we played gift swap games at the New Year party and shared our memory of 2018. This year's Lab Stars are: Luxin, Pengchong, Ruixuan, Shuzhang, Yongxian, and Wei. Congratulations to everyone!
They did it again! Congratulations to Wei Tang and Pengchong Wang for winning Poster Award at the 5th Asian Chemical Biology Conference in Xi'an! We look forward to seeing broader applications of our technique in the years to come.
Congratulations to Yi Li and Zhongyu Zou for successfully defending their undergraduate theses! More Bachelor's degrees in Zou Lab! Zhongyu will soon join the Department of Chemistry at the University of Chicago as a graduate student. Yi will continue his PhD study in our department at PKU.
Wei Tang won the Best Poster Award at the PKU-UC Davis Symposium this week! During the symposium, each student gave a 3-min elevator pitch to highlight their research to the audience. Professor Alexandra Navrotsky from UC Davis presented Wei the award. The project, titled "Spatial specific RNA profiling via chromophore-assisted proximity tagging (CAP-tag)", was led jointly by Wei Tang and Pengchong Wang. Congratulations to both of you!
Three graduate students joined our lab this month! Ran Li and Gang Wang are both Chemistry majors from the CLS program, while Junqi Yang is our first PTN student. Welcome all of you!
Our work on hybrid voltage indicator is accepted in Angewandte Chemie International Edition! By site-specifically modifying microbial rhodopsin on live cell surface with organic fluorophores, we created a palette of hybrid indicators with combined merits of small molecules (bright, photostable and small in size) and proteins (genetically targetable). The best of this series, called Flare1, has submillisecond response speed and superior sensitivity than the previous generation of fluorescent protein-based sensors. It allowed us to investigate the spatial and temporal correlation of electrical coupling among mammalian cells. Future developments are underway to achieve voltage imaging in neurons or in vivo. Read more about the design and deployment of hybrid indicators to neuroscience research in our recent review in ACS Chemical Neuroscience.
As 2018 approaches, we are delighted to welcome three CCME graduate students to join our group: Yuxin Fang, Shuzhang Liu, and Ruixuan Wang. Yuxin (B.S. in Chemistry from Nankai University) did her undergraduate thesis research in our group earlier this year and has since decided to stay. Shuzhang and Ruixuan graduated from USTC and PKU, respectively. At our New Year party this week, we exchanged gifts and shared our memorable moments in 2017. We also announced our annual Lab Stars award: Luxin, Pengchong, Ying, and Wei. Congratulations and thank you all for your hard work! We are all looking forward to a productive and happy New Year!
Congratulations to Yu Wang and three Yuxin's (~ Fang, ~ Mi, ~ Duan) for successfully defending their theses and getting Bachelor's degrees! After the summer, they will all move on to the next stage of their academic careers. Yu Wang will join The Scripps Research Institute for her PhD study. Yuxin Fang will be enrolled in the PhD program at CCME, PKU. Both Yuxin Mi and Yuxin Duan will move to the UK to study at the University of Oxford.
The past decade has seen a proliferation of fluorescent voltage indicators. Given the multiple choices, each with different tradeoffs between response speed and sensitivity, brightness and spectral range, one might ask: which sensor is better? In a recent review published by our group and Prof. Adam Cohen at Harvard University, we outlined the history of these voltage indicators, highlighting those with promising characteristics for in vivo imaging. We also discussed protein engineering strategies that gave rise to these sensors, and hoped that this article will inspire novel ideas for better probes. Read about it in Current Opinion in Chemical Biology.
We are delighted to have Ruirui Ma and Yuxin Fang joining our group. Ruirui is a first year CCME graduate student with prior research interest in inorganic and physical chemistry. We are excited to integrate that background into our research focus. Yuxin is currently a senior undergraduate student from College of Chemistry at Nankai University, and will be entering CCME in the coming fall term. Welcome both of you!
As we enter the New Year, we are delighted to have four more students joining the group! Feng Yuan (B.S. in Biology), Anqi Wang (B.S. in Chemistry), and Tieqiang Yue (B.S. in Chemistry) all graduated from Cuiying Honors program at Lanzhou University. Luxin Peng majored in physical chemistry as an undergraduate at Nanjing University. This timely reinforcement will enable us to explore new research directions in the new year. Welcome all four of you!
In addition to the gift swap game as a tradition, this year's party also included a one-slide flash talk, where each one of us reflected upon our joy and happiness and achievements in the past year. Old is gone and New is here. We are looking forward to a prosperous and productive 2017! As a new tradition, we have established our annual Lab Stars award, which will be determined at the end of each year by anonymous votes from a majority of lab members. This year, our first award goes to Sicong Wang, Ying Zhou, and Yongxian Xu, to recognize their strong work ethic and outstanding contributions to the lab.
Several students joined our group in the past couple of months. Wei Tang obtained her B.S. degree from Sun Yat-sen University and was enrolled in the CLS program at PKU in 2015. She started rotation in our lab this April and has decided to stay since. Sicong Wang joined us as a Research Assistant last month. He recently graduated from Beihang University (BUAA) with a Bachelor's Degree in Biomedical Engineering. We are also pleased to have Renjie Shang (Ocean University of China) and Yongpeng Jiang (Wuhan University) join us as summer intern students. Welcome all of you!
Congratulations to Chenxi Sun (Yuanpei College, '18) and Shasha Feng (College of Life Sciences, '18) for being selected for Beijing Innovation Program for Undergraduate Research! Both awardees will receive research fund to support lab work. We are very proud of you!
Congratulations to Jiahe for defending her undergraduate research thesis! Jiahe was the first undergrad to join our lab last summer, and has been working on developing the next generation voltage sensor for her thesis. Jiahe will move to UK this summer. She is the recipient of a graduate fellowship from China Scholarship Council, which will sponsor her PhD study at the University of Oxford for the next four years. Congratulations again!
Peng Zou is honored to receive the Young Investigator Award at the 9th CNHUPO (Chinese Human Proteome) Annual Congress (2016.5.21-23, Xiamen).
Peng Zou has received Thousand Young Talents Award from Chinese Government. This will encourage and support future research efforts in our lab.
Our lab size is temporarily doubled with the arrival of five rotation students! Jianzhi Zeng, Zhentao Zi and Shumei Hu are from CLS program. Hang Cheng and Chen Qi are from PTN program. They will start exploring new project ideas in the coming two months. Welcome!
Welcome Ying Zhou and Tao Ding, two CCME first-year grad students to start rotation in our lab. Ying obtained her Bachelor of Engineering degree from Soochow University. Tao graduated from CCME at Peking University.
As the new semester starts, Jiahe Yang, a senior undergrad from School of Life Sciences, joins us to work on voltage sensor engineering for her thesis. Welcome on board!
Lab renovation is completed. Our space is divided into four areas: optics room, tissue culture room, wet lab, and student office. The first two areas are built within a clean room.
Tongyao Wei joins our lab as research assistant. He recently graduated from School of Life Sciences at Lanzhou University. Jing Zhang joins us as administrative assistant. Welcome both of you!
Welcome the first two Zou lab members: Yongxian Xu and Pengchong Wang! Both are enrolled in the CLS program. Yongxian obtained his MS degree from Zhejiang University. Pengchong graduated from Shandong University.