Congratulations to Shuzhang for winning the poster award! He presented a bright and sensitive far-red voltage indicator for visualizing membrane potential dynamics in cultured neurons.
Check out our CAP-seq technique for mapping subcellular RNA localization at Nat Chem Biol! We employed a genetically encoded photosensitizer to achieve light-activated, proximity-dependent RNA oxidation, which allowed us to examine the local transcriptomes at various subcellular compartments. CAP-seq has high spatiotemporal resolution and is easy to use. We look forward to seeing more of its applications in the near future! We thank our collaborator, Prof. Jianbin Wang from Tsinghua University. Congratulations to Pengchong, Wei and Zeyao!
Congratulations to Yongxian Xu (on 9/6) and Pengchong Wang (on 9/10) for defending their doctoral theses!
Peng Zou has been selected by Chemical and Engineering News (C&EN) as a member of this year's Talented 12 list. This program is presented annually by the weekly newsmagazine and recognizes 12 young stars in the chemical sciences who are "working to solve some of the world's most challenging problems". This news was announced at the American Chemical Society National Meeting in San Diego, CA.
Congratulations to Xiaotian, Ziqi, Chang, and Liyuan (left to right) for getting their Bachelor's degrees! Ziqi and Chang will continue their study at PKU as graduate students. Xiaotian (Caltech) and Liyuan (Princeton) will start their PhD journey in the US after the summer. We look forward to seeing your continued success in the years to come. Congratulations again to all of you!
Check out our new panel of APEX substrates in Angewandte Chemie International Edition! We synthesized a series of aromatic compounds and identified arylamines as efficient probes for labeling RNA and DNA. Using the mitochondria as a model, we demonstrated proximity-dependent RNA capture with exceptional spatial-specificity and high coverage. Congratulations to Ying and Gang! This is our first venture into the RNA world.
Yi Li, Ruixiang Wang, and Xinyue Zhou joined our lab as first graduate students. Yi did his undergrad research in our group and has since decided to stay. Both Ruixiang and Xinyue were from Nankai University. They are enrolled in CLS program and have recently finished rotations. They will work on research projects related to proximity proteomic labeling.
As a lab tradition, we played gift swap games at the New Year party and shared our memory of 2018. This year's Lab Star Award goes to: Luxin, Pengchong, Ruixuan, Shuzhang, Yongxian, and Wei. Congratulations to everyone!
They did it again! Congratulations to Wei Tang and Pengchong Wang for winning Poster Award at the 5th Asian Chemical Biology Conference in Xi'an! We look forward to seeing broader applications of our technique in the years to come.
Congratulations to Yi Li and Zhongyu Zou for successfully defending their undergraduate theses! More Bachelor's degrees in Zou Lab! Zhongyu will soon join the Department of Chemistry at the University of Chicago as a graduate student. Yi will continue his PhD study in our department at PKU.
Wei Tang won the Best Poster Award at the PKU-UC Davis Symposium this week! During the symposium, each student gave a 3-min elevator pitch to highlight their research to the audience. Professor Alexandra Navrotsky from UC Davis presented Wei the award. The project, titled "Spatial specific RNA profiling via chromophore-assisted proximity tagging (CAP-tag)", was led jointly by Wei Tang and Pengchong Wang. Congratulations to both of you!
Three graduate students joined our lab this month! Ran Li and Gang Wang are both Chemistry majors from the CLS program, while Junqi Yang is our first PTN student. Welcome to all of you!
Our work on hybrid voltage indicator is accepted in Angewandte Chemie International Edition! By site-specifically modifying microbial rhodopsin on live cell surface with organic fluorophores, we created a palette of hybrid indicators with combined merits of small molecules (bright, photostable and small in size) and proteins (genetically targetable). The best of this series, called Flare1, has submillisecond response speed and superior sensitivity than the previous generation of fluorescent protein-based sensors. It allowed us to investigate the spatial and temporal correlation of electrical coupling among mammalian cells. Future developments are underway to achieve voltage imaging in neurons or in vivo. Read more about the design and deployment of hybrid indicators to neuroscience research in our recent review in ACS Chemical Neuroscience.
As 2018 approaches, we are delighted to welcome three CCME graduate students to join our group: Yuxin Fang, Shuzhang Liu, and Ruixuan Wang. Yuxin (B.S. in Chemistry from Nankai University) did her undergraduate thesis research in our group earlier this year and has since decided to stay. Shuzhang and Ruixuan graduated from USTC and PKU, respectively. At our New Year party this week, we exchanged gifts and shared our memorable moments in 2017. We also announced our annual "Lab Star" awards: Luxin, Pengchong, Ying, and Wei. Congratulations and thank you all for your hard work! We are all looking forward to a productive and happy New Year!
Congratulations to Yu Wang and three Yuxin's (~ Fang, ~ Mi, ~ Duan) for successfully defending their theses and getting Bachelor's degrees! After the summer, they will all move on to the next stage of their academic careers. Yu Wang will join The Scripps Research Institute for her PhD study. Yuxin Fang will be enrolled in the PhD program at CCME, PKU. Both Yuxin Mi and Yuxin Duan will move to the UK to study at the University of Oxford.
The past decade has seen a proliferation of fluorescent voltage indicators. Given the multiple choices, each with different tradeoffs between response speed and sensitivity, brightness and spectral range, one might ask: which sensor is better? In a recent review published by our group and Prof. Adam Cohen at Harvard University, we outlined the history of these voltage indicators, highlighting those with promising characteristics for in vivo imaging. We also discussed protein engineering strategies that gave rise to these sensors, and hoped that this article will inspire novel ideas for better probes. Read about it in Current Opinion in Chemical Biology.
We are delighted to have Ruirui Ma and Yuxin Fang joining our group. Ruirui is a first year CCME graduate student with prior research interest in inorganic and physical chemistry. We are excited to integrate that background into our research focus. Yuxin is currently a senior undergraduate student from College of Chemistry at Nankai University, and will be entering CCME in the coming fall term. Welcome to both of you!
As we enter the New Year, we are delighted to have four more students joining the group! Feng Yuan (B.S. in Biology), Anqi Wang (B.S. in Chemistry), and Tieqiang Yue (B.S. in Chemistry) all graduated from Cuiying Honors program at Lanzhou University. Luxin Peng majored in physical chemistry as an undergraduate at Nanjing University. This timely reinforcement will enable us to explore new research directions in the new year. Welcome to all four of you!
In addition to the gift swap game as a tradition, this year's party also included a one-slide flash talk, where each one of us reflected upon our joy and happiness and achievements in the past year. Old is gone and New is here. We are looking forward to a prosperous and productive 2017! As a new tradition, we have established our annual "Lab Star" award, which will be determined at the end of each year by anonymous votes from a majority of lab members. This year, our first award goes to Sicong Wang, Ying Zhou, and Yongxian Xu, to recognize their strong work ethic and outstanding contributions to the lab.
Several students joined our group in the past couple of months. Wei Tang obtained her B.S. degree from Sun Yat-sen University and was enrolled in the CLS program at PKU in 2015. She started rotation in our lab this April and has decided to stay since. Sicong Wang joined us as a Research Assistant last month. He recently graduated from Beihang University (BUAA) with a Bachelor's Degree in Biomedical Engineering. We are also pleased to have Renjie Shang (Ocean University of China) and Yongpeng Jiang (Wuhan University) join us as summer intern students. Welcome to all of you!
Congratulations to Chenxi Sun (Yuanpei College, '18) and Shasha Feng (College of Life Sciences, '18) for being selected for Beijing Innovation Program for Undergraduate Research! Both awardees will receive research fund to support lab work. We are very proud of you!
Congratulations to Jiahe for defending her undergraduate research thesis! Jiahe was the first undergrad to join our lab last summer, and has been working on developing the next generation voltage sensor for her thesis. Jiahe will move to UK this summer. She is the recipient of a graduate fellowship from China Scholarship Council, which will sponsor her PhD study at Oxford University for the next four years. Congratulations again!
Peng Zou is honored to receive the Young Investigator Award at the 9th CNHUPO (Chinese Human Proteome) Annual Congress (2016.5.21-23, Xiamen).
Peng Zou has received Thousand Young Talents Award from Chinese Government. This will encourage and support future research efforts in our lab.
Our lab size is temporarily doubled with the arrival of five rotation students! Jianzhi Zeng, Zhentao Zi and Shumei Hu are from CLS program. Hang Cheng and Chen Qi are from PTN program. They will start exploring new project ideas in the coming two months. Welcome!
Welcome to Ying Zhou and Tao Ding, two CCME first-year grad students to start rotation in our lab. Ying obtained her Bachelor of Engineering degree from Soochow University. Tao graduated from CCME at Peking University.
As the new semester starts, Jiahe Yang, a senior undergrad from School of Life Sciences, joins us to work on voltage sensor engineering for her thesis. Welcome on board!
Lab renovation is completed. Our space is divided into four areas: optics room, tissue culture room, wet lab, and student office. The first two areas are built within a clean room.
Tongyao Wei joins our lab as research assistant. He recently graduated from School of Life Sciences at Lanzhou University. Jing Zhang joins us as administrative assistant. Welcome to both!
Welcome to the first two Zou lab members: Yongxian Xu and Pengchong Wang! Both are enrolled in the CLS program. Yongxian obtained his MS degree from Zhejiang University. Pengchong graduated from Shandong University.